A modulatory effect of extracellular Ca2+ on type 1α metabotropic glutamate receptor-mediated signalling

被引：49

作者：

Saunders, R ^{[1
]}

Nahorski, SR ^{[1
]}

Challiss, RAJ ^{[1
]}

机构：

[1] Univ Leicester, Dept Cell Physiol & Pharmacol, Leicester LE1 9HN, Leics, England

来源：

NEUROPHARMACOLOGY | 1998年 / 37卷 / 02期

基金：

英国医学研究理事会;

关键词：

mGlul alpha receptor; M-3-muscarinic receptor; phosphoinositide hydrolysis; calcium; extracellular; baby hamster kidney cells;

D O I：

10.1016/S0028-3908(98)00027-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Increasing [Ca2+](e) from 1.3-4 mM had little effect on basal phospholipase C activity in baby hamster kidney (BHK) cells stably expressing either type in metabotropic glutamate (mGlu1 alpha) or M-3-muscarinic (m3) receptors, but enhanced agonist-stimulated phosphoinositide hydrolysis in BHK-mGlu1 alpha, bur not BHK-m3 cells, demonstrating that Ca(e)(2+)selectively modulates phosphoinositide signalling stimulated by this receptor subtype. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：273 / 276

页数：4

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