Immunogenicity and safety of a combined hepatitis A and B vaccine administered concomitantly with either a measles-mumps-rubella or a diphtheria-tetanus-acellular pertussis-inactivated poliomyelitis vaccine mixed with a Haemophilus influenzae type b conjugate vaccine in infants aged 12-18 months

被引：12

作者：

Usonis, V

Meriste, S

Bakasenas, V

Lutsar, I

Collard, F

Stoffeld, A

Tornieporth, N

机构：

[1] Vilnius State Univ, Ctr Pardiat, LT-2009 Vilnius, Lithuania

[2] Univ Tartu, Childrens Hosp, EE-51014 Tartu, Estonia

[3] Ctr Communicable Dis Prevent & Control, LT-2600 Vilnius, Lithuania

[4] GlaxoSmithKline Biol, Rixensart, Belgium

来源：

VACCINE | 2005年 / 23卷 / 20期

关键词：

hepatitis A/B vaccine; DTPa-IPV/Hib; NIMR; concomitant vaccination;

D O I：

10.1016/j.vaccine.2004.11.062

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two studies were undertaken to investigate the concomitant administration of combined hepatitis A/B vaccine with a diphtheria-tetanus-acellular pertussis-inactivated poliomyelitis vaccine mixed with Haemophilus influenzae vaccine (DTPa-IPV/Hib), or with a measles-mumps-rubella vaccine (MMR), during the second year of life. On completion of the vaccination course, all subjects were seropositive or seroprotected against all antigens except for one subject who was seronegative for anti-PT. Seropositivity and seroprotection rates for all other antibodies were comparable to reference values for each vaccine component, indicating that the immunogenicity of MMR, DTPa-IPV/Hib and combined hepatitis A/B vaccines is not impaired by co-administration. All vaccines were well tolerated. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2602 / 2606

页数：5

共 12 条

[1] Development and clinical application of new polyvalent combined paediatric vaccines [J].