Extrahepatic manifestations of cholestatic liver diseases

被引：24

作者：

Pusl, T ^{[1
]}

Beuers, U ^{[1
]}

机构：

[1] Klinikum Univ Munich Grosshadern, Dept Med 2, Munich, Germany

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2005年 / 28卷 / 02期

关键词：

cholestasis; primary biliary cirrhosis; primary sclerosing cholangitis; pruritus; fatigue; metabolic bone disease; osteoporosis; extrahepatic; pathogenesis; symptoms;

D O I：

10.1385/CRIAI:28:2:147

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 [免疫学];

摘要：

Pruritus, fatigue, and metabolic bone disease are frequent complications of cholestatic liver diseases, which can be quite distressing for the patient and can considerably reduce the quality of life. The molecular pathogenesis of these extrahepatic manifestations of cholestasis is poorly understood, and hypotheses to explain these symptoms are being discussed. This article provides treatment recommendations for the complications of cholestasis based on putative pathomechanisms and summarizes recent experimental and clinical data involving management options.

引用

页码：147 / 157

页数：11

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