Insulin in the Management of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

OBJECTIVE: The role of tight glycemic control in the management of acute ischemic stroke remains uncertain. Our goal is to evaluate the effects of tight glucose control with insulin therapy after acute ischemic stroke. METHODS: We searched PubMed, CENTRAL, and Embase for randomized controlled trials (RCTs) that evaluated the effects of tight glycemic control (70-135 mg/dL) in acute ischemic stroke. Analysis was performed using fixed-effects and random-effects models. Outcomes were death, independence, and modified Rankin Scale (mRS) score at >= 90 days follow-up, and symptomatic or severe hypoglycemia during treatment. RESULTS: Twelve RCTs including 2734 patients were included. Compared with conventional therapy or placebo, tight glycemic control was associated with similar rates of mortality at >= 90 days follow-up (pooled odds ratio [pOR], 0.99; 95% confidence interval [Cl], 0.79-1.22); I-2 = 0%), independence at >= 90 days follow-up (pOR, 0.95; 95% CI, 0.79- .1.14; I-2 = 0%) and mRS scores at >= 90 days follow-up (standardized mean difference, 0.014; 95% CI, -0.15 to 0.17; I-2 = 0%). In contrast, tight glycemic control was associated with increased rates of symptomatic or severe hypoglycemia during treatment (pOR, 5.Z 95% CI, 1.7- 15.9; I-2 = 28%). CONCLUSIONS: Tight glucose control after acute ischemic stroke is not associated with improvements in mortality, independence, or mRS score and leads to higher rates of symptomatic or severe hypoglycemia.