Exons, introns, and DNA thermodynamics

被引：29

作者：

Carlon, E

Malki, ML

Blossey, R

机构：

[1] Interdisciplinary Res Inst, IEMN, F-59652 Villeneuve Dascq, France

[2] Ecole Natl Super Phys Strasbourg, F-67412 Illkirch Graffenstaden, France

来源：

PHYSICAL REVIEW LETTERS | 2005年 / 94卷 / 17期

关键词：

D O I：

10.1103/PhysRevLett.94.178101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The genes of eukaryotes are characterized by protein coding fragments, the exons, interrupted by introns, i.e., stretches of DNA which do not carry useful information for protein synthesis. We have analyzed the melting behavior of randomly selected human cDNA sequences obtained from genomic DNA by removing all introns. A clear correspondence is observed between exons and melting domains. This finding may provide new insights into the physical mechanisms underlying the evolution of genes.

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页数：4

相关论文

共 20 条

[1]

Alberts B., 2002, Molecular Biology of The Cell, V4th

[2] DO GENES-IN-PIECES IMPLY PROTEINS-IN-PIECES [J].

BLAKE, CCF .

NATURE, 1978, 273 (5660) :267-267

[3] Statistical mechanical simulation of polymeric DNA melting with MELTSIM [J].

Blake, RD ;

Bizzaro, JW ;

Blake, JD ;

Day, GR ;

Delcourt, SG ;

Knowles, J ;

Marx, KA ;

SantaLucia, J .

BIOINFORMATICS, 1999, 15 (05) :370-375

[4] Reparametrizing the loop entropy weights: Effect on DNA melting curves [J].

Blossey, R ;

Carlon, E .

PHYSICAL REVIEW E, 2003, 68 (06)

[5] SELFISH DNA AND THE ORIGIN OF INTRONS [J].

CAVALIERSMITH, T .

NATURE, 1985, 315 (6017) :283-284

[6] Origins of recently gained introns in Caenorhabditis [J].

Coghlan, A ;

Wolfe, KH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (31) :11362-11367

[7] EVIDENCE THAT INTRONS AROSE AT PROTO-SPLICE SITES [J].

DIBB, NJ ;

NEWMAN, AJ .

EMBO JOURNAL, 1989, 8 (07) :2015-2021

[8] THE EXON THEORY OF GENES [J].

GILBERT, W .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1987, 52 :901-905

[9] WHY GENES IN PIECES [J].

GILBERT, W .

NATURE, 1978, 271 (5645) :501-501

[10] Comparison of experimental to MELTSIM calculated DNA melting of the (A+T) rich Dictyostelium discoideum genome:: Denaturation maps distinguish exons from introns [J].

Marx, KA ;

Assil, IQ ;

Bizzaro, JW ;

Blake, RD .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1998, 16 (02) :329-339