A multicenter study of the efficacy and safety of leukocytapheresis therapy without concomitant systemic steroid treatment in patients with active ulcerative colitis

被引：9

作者：

Ashida, Toshifumi ^{[1
,2
]}

Kohgo, Yutaka ^{[2
]}

Munakata, Akihiro ^{[3
]}

Noguchi, Mitsunori ^{[4
]}

Iizuka, Bunei ^{[5
]}

Endo, Yutaka ^{[6
]}

Hanai, Hiroyuki ^{[7
]}

Yoshikawa, Toshikazu ^{[8
]}

Matsumoto, Takayuki ^{[9
]}

Aoyama, Nobuo ^{[10
]}

Matsui, Toshiyuki ^{[11
]}

Mitsuyama, Keiichi ^{[12
]}

Hibi, Toshifumi ^{[13
]}

机构：

[1] Sapporo Higashi Tokushukai Hosp, IBD Ctr, Sapporo, Hokkaido 0650033, Japan

[2] Asahikawa Med Coll, Dept Internal Med 3, Asahikawa, Hokkaido 078, Japan

[3] Hirosaki Univ, Sch Medicine, Dept Internal Med 1, Hirosaki, Aomori, Japan

[4] Sendai Social Insurance Hosp, Dept Gastroenterol, Sendai, Miyagi, Japan

[5] Tokyo Womens Med Univ, Inst Gastroenterol, Tokyo, Japan

[6] Showa Univ, Fujigaoka Hosp, Div Gastroenterol, Tokyo, Japan

[7] Hamamatsu Univ Sch Med, Dept Endoscop & Photodynam Med, Hamamatsu, Shizuoka, Japan

[8] Kyoto Prefectural Univ Med, Dept Med, Kyoto 602, Japan

[9] Hyogo Coll Med, Dept Internal Med, Div Lower Gastroenterol, Nishinomiya, Hyogo, Japan

[10] Kobe Univ Hosp, Dept Endoscopy, Kobe, Hyogo, Japan

[11] Fukuoka Univ, Chikushi Hosp, Dept Gastroenterol, Fukuoka, Japan

[12] Kurume Univ, Sch Med, Dept Med, Div Gastroenterol, Kurume, Fukuoka, Japan

[13] Keio Univ, Sch Med, Dept Internal Med, Tokyo 108, Japan

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2011年 / 44卷 / 02期

关键词：

INFLAMMATORY-BOWEL-DISEASE; TERM CORTICOSTEROID-THERAPY; NAIVE PATIENTS; APHERESIS; GRANULOCYTE; MANAGEMENT; TRIAL;

D O I：

10.1016/j.transci.2011.01.001

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

We conducted a multicenter study to investigate the efficacy of leukocytapheresis (LCAP) without concomitant steroid therapy in active ulcerative colitis (UC) patients. Twenty patients were enrolled. LCAP was performed twice a week for 3 weeks. The results revealed a significant decrease of the Lichtiger's clinical activity index (CAI) from 11.7 +/- 2.6 at base-line to 6.6 +/- 4.1 after the therapy. The endoscopic index and serum C-reactive protein levels also decreased significantly after the therapy. Of the 20 patients, 15(75%) were assessed as responders (CAI <= 4 or Delta CAI >= 3), and 7 (35%) achieved complete remission (CAI <= 4). No serious adverse reactions were encountered. The results suggest that LCAP is an effective and safe option for patients with active UC who had not received systemic steroid treatment. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：113 / 117

页数：5

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