The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

被引：429

作者：

Adrain, C ^{[1
]}

Martin, SJ ^{[1
]}

机构：

[1] Trinity Coll Dublin, Smurfit Inst, Dept Genet, Mol Cell Biol Lab, Dublin 2, Ireland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(01)01844-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The caspase family of cysteine proteases have emerged as central regulators of apoptosis. Diverse cellular stresses trigger caspase activation by promoting release of mitochondrial components, including cytochrome c, into the cytoplasm,ln turn, cytochrome c promotes the assembly of a caspase-activating complex termed the apoptosome. In this article, the apoptosome and its role in life and death decisions of cells are discussed.

引用

页码：390 / 397

页数：8

共 50 条

[1] Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region [J].

Adrain, C ;

Slee, EA ;

Harte, MT ;

Martin, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) :20855-20860

[2] Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome [J].

Beere, HM ;

Wolf, BB ;

Cain, K ;

Mosser, DD ;

Mahboubi, A ;

Kuwana, T ;

Tailor, P ;

Morimoto, RI ;

Cohen, GM ;

Green, DR .

NATURE CELL BIOLOGY, 2000, 2 (08) :469-475

[3] Expression and functional analysis of Apaf-1 isoforms -: Extra WD-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9 [J].

Benedict, MA ;

Hu, YM ;

Inohara, N ;

Núñez, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :8461-8468

[4] Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization [J].

Bossy-Wetzel, E ;

Newmeyer, DD ;

Green, DR .

EMBO JOURNAL, 1998, 17 (01) :37-49

[5] Apaf-1 oligomerizes into biologically active ∼700-kDa and inactive ∼1.4-MDa apoptosome complexes [J].

Cain, K ;

Bratton, SB ;

Langlais, C ;

Walker, G ;

Brown, DG ;

Sun, XM ;

Cohen, GM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (09) :6067-6070

[6] Caspase activation involves the formation of the aposome, a large (∼700 kDa) caspase-activating complex [J].

Cain, K ;

Brown, DG ;

Langlais, C ;

Cohen, GM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (32) :22686-22692

[7] Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death [J].

Chen, FL ;

Hersh, BM ;

Conradt, B ;

Zhou, Z ;

Riemer, D ;

Gruenbaum, Y ;

Horvitz, HR .

SCIENCE, 2000, 287 (5457) :1485-1489

[8] Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death [J].

Chinnaiyan, AM ;

ORourke, K ;

Lane, BR ;

Dixit, VM .

SCIENCE, 1997, 275 (5303) :1122-1126

[9] The C-elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9 [J].

Conradt, B ;

Horvitz, HR .

CELL, 1998, 93 (04) :519-529

[10] Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis [J].

Desagher, S ;

Osen-Sand, A ;

Nichols, A ;

Eskes, R ;

Montessuit, S ;

Lauper, S ;

Maundrell, K ;

Antonsson, B ;

Martinou, JC .

JOURNAL OF CELL BIOLOGY, 1999, 144 (05) :891-901

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