Are spirolides converted in biological systems? - A study

被引：16

作者：

Christian, Bernd ^{[1
]}

Below, Anja ^{[1
]}

Dressler, Nicole ^{[1
]}

Scheibner, Olaf ^{[2
]}

Luckas, Bernd ^{[1
]}

Gerdts, Gunnar ^{[3
]}

机构：

[1] Univ Jena, Inst Nutr, D-07749 Jena, Germany

[2] Hans Knoell Inst, Leiden Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany

[3] Alfred Wegener Inst Polar & Marine Res, D-27483 Helgoland, Germany

来源：

TOXICON | 2008年 / 51卷 / 05期

关键词：

spirolides; shellfish; LC-MS analyses; Alexandrium ostenfeldii;

D O I：

10.1016/j.toxicon.2007.12.019

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Spirolides are biologically active macrocycles isolated first from scallops and phytoplankton from aquaculture sites in Nova Scotia. Canada. These compounds displayed "fast-acting" toxicity in the traditional bioassay. That phenomenon is related to the presence of a cyclic imine function in these compounds. Spirolides containing vicinal methyl groups in their seven-membered ring are suspected of being resistant to hydrolysis. We studied possible conversions of vicinal methyl groups wearing spirolides of Alexandrium ostenfeldii KO287 in enzymatic cell-free tissue extracts of Mytilus edulis, Pecten maximus and Crassostrea gigas. Our observations suggest that spirolides that contain an extra methyl group on the imine ring compared with spirolide A and B survive enzymatic hydrolysis conditions in shellfish and therefore may be toxic for human beings when shellfish is consumed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：934 / 940

页数：7

共 14 条

[1]

Detection and identification of spirolides in Norwegian shellfish and plankton [J].