New horizons in early stage COPD - Improving knowledge, detection and treatment

被引：38

作者：

Decramer, Marc ^{[2
]}

Miravitlles, Marc ^{[1
]}

Price, David ^{[3
]}

Roman-Rodriguez, Miguel ^{[4
]}

Llor, Carl ^{[5
]}

Welte, Tobias ^{[6
]}

Buhl, Roland ^{[7
]}

Dusser, Daniel ^{[8
]}

Samara, Katerina ^{[9
]}

Siafakas, Nikolaus ^{[9
]}

机构：

[1] Hosp Clin Barcelona, Serv Pneumol, CIBER Enfermedades Resp CIBERES,Fundacio Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, E-08036 Barcelona, Spain

[2] Univ Louvain, Div Resp, Louvain, Belgium

[3] Univ Aberdeen, Ctr Acad Primary Care, Foresterhill Hlth Ctr, Aberdeen, Scotland

[4] Son Pisa Hlth Ctr IB Salut Balear Goverment, Palma De Mallorca, Baleares, Spain

[5] Univ Rovira & Virgili, Primary Healthcare Ctr Jaume I, Tarragona, Spain

[6] Hannover Med Sch, Dept Resp Med, Hannover, Germany

[7] Mainz Univ Hosp, Dept Pulm, Mainz, Germany

[8] Univ Paris Descarte, Hop Cochin, APHP, Paris, France

[9] Univ Gen Hosp, Dept Thorac Med, Iraklion, Greece

来源：

RESPIRATORY MEDICINE | 2011年 / 105卷 / 11期

关键词：

COPD; Early disease; Treatment; Diagnosis; Case-finding; OBSTRUCTIVE PULMONARY-DISEASE; QUALITY-OF-LIFE; AIR-FLOW OBSTRUCTION; LUNG-FUNCTION; PRIMARY-CARE; HIGH-RISK; INHALED BUDESONIDE; PHYSICAL-ACTIVITY; GENERAL-PRACTICE; GOLD STAGE;

D O I：

10.1016/j.rmed.2010.12.015

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Early stage COPD carries a significant healthcare burden that is currently underrecognised, underdiagnosed and undertreated. Furthermore, patients at this stage can rapidly decline to advanced disease, especially if they continue to smoke. The natural history of the disease in early stages remains largely unknown, and emerging evidence indicates that we are able to reduce lung function decline and exacerbations, and improve quality of life, in early stage COPD, mainly through smoking cessation. But new evidence from randomised clinical trials also suggests an impact of pharmacotherapy on clinical outcomes in early disease. Guidelines need to be updated to reflect this greater understanding of early stage disease, and trials need to be conducted to definitively show the benefits of intensive treatment so that we can meet the large, unmet clinical needs of this important patient group. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1576 / 1587

页数：12

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