Progress - A technicolour approach to the connectome

被引：214

作者：

Lichtman, Jeff W. ^{[1
,2
]}

Livet, Jean ^{[3
,4
]}

Sanes, Joshua R. ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA

[3] INSERM, UMR S592, Inst Vision, F-75012 Paris, France

[4] Univ Paris 06, UMR S592, F-75005 Paris, France

来源：

NATURE REVIEWS NEUROSCIENCE | 2008年 / 9卷 / 06期

关键词：

D O I：

10.1038/nrn2391

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A central aim of neuroscience is to map neural circuits, in order to learn how they account for mental activities and behaviours and how alterations in them lead to neurological and psychiatric disorders. However, the methods that are currently available for visualizing circuits have severe limitations that make it extremely difficult to extract precise wiring diagrams from histological images. Here we review recent advances in this area, along with some of the opportunities that these advances present and the obstacles that remain.

引用

页码：417 / 422

页数：6

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