New efficient synthesis of ω-aminoalkylidene-1,1-bisphosphonate tetraethylesters

被引:10
作者
Gourves, JP [1 ]
Couthon, H [1 ]
Sturtz, G [1 ]
机构
[1] Univ Brest, Lab Chim Heteroorgan, F-29285 Brest, France
关键词
tetraethyl omega-aminoalkylidenebisphosphonates and omega-hydroxy-alkylidenebisphosphonates; methylidenebisphosphonate; amination;
D O I
10.1080/10426509808036988
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Bisphosphonates are interesting therapeutic agents in the management of bone diseases and since several years our laboratory has been developing the chemistry of 1,1-bisphosphonates, This paper describes an original synthesis of two aminoalkylidenebisphosphonates by first preparing the intermediate hydroxyalkylidenebisphosphonates which are transformed into amines via the azides.
引用
收藏
页码:219 / 229
页数:11
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