Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline (vol 14, pg 63S, 2007)

被引：24

作者：

Behera, Millie A.

机构：

[1] Department of Obstetrics and Gynecology, Medical Center, Duke University, Box 3279, Durham, 27710, NC

[2] Uniformed Services University, Department of Obstetrics and Gynecology, Bethesda, MD

[3] Duke University, Department of Biostatistics and Bioinformatics, Durham, NC

[4] Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, Bethesda, MD

来源：

REPRODUCTIVE SCIENCES | 2008年 / 15卷 / 01期

基金：

美国国家卫生研究院;

关键词：

collagen; fibroisis; leiomyomata; thrombospondins; Uterine fibroids;

D O I：

10.1177/1933719107309591

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Uterine fibroids are composed of altered collagen fibrils and represent an arrested response to injury-initiating fibrosis. In many tissues, TSP-1 is secreted by adult macrophages and monocytes upon wounding and is involved in the activation of transforming growth factor β. In the absence of TSP-1, the orchestrated process of wound healing is impaired. The authors obtained tissue from the edge and center of fibroids at the time of hysterectomy and compared them with adjacent myometrium. The pattern of TSP-1 and TSP-2 expression was correlated to that of COL1A1 and COL3A1. Collagen and hydroxyproline were increased in fibroids. Thrombospondin-1 was consistently underexpressed in both the edge and center of the fibroids, while COL1A1 and COL3A1 were consistently overexpressed. However, TSP-2 was inconsistently expressed. These findings lead to the conclusion that the underexpression of TSP-1 may contribute to the overall development of uterine fibroids. © 2007 by the Society for Gynecologic Investigation.

引用

页码：97 / 97

页数：1