Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein

被引：125

作者：

Arold, ST

Bauer, AS

机构：

[1] Fac Pharm Montpellier, Ctr Biochim Struct, CNRS,UMR C5048, INSERM,U553, F-34060 Montpellier, France

[2] Univ Erlangen Nurnberg, Dept Dermatol, D-91052 Erlangen, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 06期

关键词：

D O I：

10.1016/S0968-0004(01)01846-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Nef protein of the human immunodeficiency virus is as important for disease progression:as it is perplexing in its plethora of target molecules and functions. In this article, it is proposed that the complex biology of Nef is regulated through conformational changes of the protein that are triggered by cellular location and specific interactions as Nef traffics through the infected cell.

引用

页码：356 / 363

页数：8

共 50 条

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