Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial

Background/Objectives: In vitro and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients. Subjects/Methods: A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (n = 27), 5 g/d BSP (n = 29) or placebo (n = 25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment. Results: In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (n = 21), 5 g/d (n = 22) and placebo (n = 20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (P = 0.001 for treatment effect), oxidized low density lipoprotein cholesterol (P = 0.03 for treatment effect), OSI (P 0.001 for treatment effect) and significant increase in TAC (P 0.001 for treatment effect). No effects were found on TOS. Conclusion: BSP had favorable effects on oxidative stress status in type 2 diabetes patients. European Journal of Clinical Nutrition (2011) 65, 972-977; doi:10.1038/ejcn.2011.59; published online 11 May 2011