Uptake of binary actin ADP-ribosylating toxins

被引：10

作者：

Barth, H ^{[1
]}

机构：

[1] Univ Freiburg, Inst Expt & Klin Pharmakol & Toxicol, D-79104 Freiburg, Germany

来源：

REVIEWS OF PHYSIOLOGY, BIOCHEMICAL AND PHARMACOLOGY, VOL 152 | 2005年 / 152卷

关键词：

D O I：

10.1007/s10254-004-0029-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The focus of this article is on the cellular uptake mechanism of the family of binary actin ADP-ribosylating toxins from clostridia. These toxins are special-type AB toxins, because they are composed of two nonlinked proteins, which have to assemble on the surface of eukaryotic cells to act cytotoxically. The enzymatically active component (A), ADP-ribosylates G-actin in the cytosol of target cells. This leads to a complete depolymerization of the actin filaments and, thereby, to rounding up of cultured cells. The second component of these toxins, the binding/translocation component (B), mediates the transport of the enzyme component into the cytosol.

引用

页码：165 / 182

页数：18

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