Detection of novel point mutations in the Plasmodium falciparum ATPase6 candidate gene for resistance to artemisinins

被引:29
作者
Menegon, Michela [1 ]
Sannella, Anna Rosa [1 ]
Majori, Giancarlo [1 ]
Severini, Carlo [1 ]
机构
[1] Ist Super Sanita, Dept Infect Parasit & Immunomediated Dis, I-00161 Rome, Italy
关键词
D O I
10.1016/j.parint.2007.12.004
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
[No abstract available]
引用
收藏
页码:233 / 235
页数:3
相关论文
共 15 条
[1]   Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (Encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10 [J].
Afonso, A ;
Hunt, P ;
Cheesman, S ;
Alves, AC ;
Cunha, CV ;
do Rosário, V ;
Cravo, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (02) :480-489
[2]   Resistance to dihydroartemisinin [J].
Cojean, Sandrine ;
Hubert, Veronique ;
Le Bras, Jacques ;
Durand, Remy .
EMERGING INFECTIOUS DISEASES, 2006, 12 (11) :1798-1799
[3]   The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin [J].
Duraisingh, MT ;
Jones, P ;
Sambou, I ;
von Seidlein, L ;
Pinder, M ;
Warhurst, DC .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2000, 108 (01) :13-23
[4]   Artemisinins target the SERCA of Plasmodium falciparum [J].
Eckstein-Ludwig, U ;
Webb, RJ ;
van Goethem, IDA ;
East, JM ;
Lee, AG ;
Kimura, M ;
O'Neill, PM ;
Bray, PG ;
Ward, SA ;
Krishna, S .
NATURE, 2003, 424 (6951) :957-961
[5]   Current perspectives on the mechanism of action of artemisinins [J].
Golenser, Jacob ;
Waknine, Judith H. ;
Krugliak, Miriam ;
Hunt, Nicholas H. ;
Grau, Georges E. .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2006, 36 (14) :1427-1441
[6]   Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6 [J].
Jambou, R ;
Legrand, E ;
Niang, M ;
Khim, N ;
Lim, P ;
Volney, B ;
Ekala, MT ;
Bouchier, C ;
Esterre, P ;
Fandeur, T ;
Mercereau-Puijalon, O .
LANCET, 2005, 366 (9501) :1960-1963
[7]   STAGE-SPECIFIC GAMETOCYTOCIDAL EFFECT INVITRO OF THE ANTIMALARIA DRUG QINGHAOSU ON PLASMODIUM-FALCIPARUM [J].
KUMAR, N ;
HONG, Z .
PARASITOLOGY RESEARCH, 1990, 76 (03) :214-218
[8]   Analysis of pfcrt, pfmdr1, dhfr, and DHPS mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin [J].
Ngo, T ;
Duraisingh, M ;
Reed, M ;
Hipgrave, D ;
Biggs, B ;
Cowman, AF .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2003, 68 (03) :350-356
[9]   Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number [J].
Price, RN ;
Uhlemann, AC ;
Brockman, A ;
McGready, R ;
Ashley, E ;
Phaipun, L ;
Patel, R ;
Laing, K ;
Looareesuwan, S ;
White, NJ ;
Nosten, F ;
Krishna, S .
LANCET, 2004, 364 (9432) :438-447
[10]   Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum [J].
Reed, MB ;
Saliba, KJ ;
Caruana, SR ;
Kirk, K ;
Cowman, AF .
NATURE, 2000, 403 (6772) :906-909