Poor treatment outcome of Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia despite intensive chemotherapy

被引：29

作者：

Uckun, FM ^{[1
]}

Nachman, JB ^{[1
]}

Sather, HN ^{[1
]}

Sensel, MG ^{[1
]}

Kraft, P ^{[1
]}

Steinherz, PG ^{[1
]}

Lange, B ^{[1
]}

Hutchinson, R ^{[1
]}

Reaman, GH ^{[1
]}

Gaynon, PS ^{[1
]}

Heerema, NA ^{[1
]}

机构：

[1] Childrens Canc Grp, ALL Biol Reference Lab, St Paul, MN 55113 USA

来源：

LEUKEMIA & LYMPHOMA | 1999年 / 33卷 / 1-2期

关键词：

Philadelphia chromosome; children; acute lymphoblastic leukemia; cytogenetics;

D O I：

10.3109/10428199909093730

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Children with Philadelphia (Ph) chromosome positive ((+)) acute lymphoblastic leukemia (ALL) represent a subgroup at very high risk for treatment failure. This study included 1322 children enrolled between 1988 and 1994 on CCG risk-adjusted studies for ALL who had centrally reviewed cytogenetic data. Thirty patients had a t(9;22) and are referred to as Phi; 1292 were Ph-. 23 of these 30 patients were treated on the CCG-1882 high risk ALL protocol. The event-free survival (EFS) outcome in CCG-1882 was significantly worse for Ph+ compared with Ph- patients, with 4-year estimates of 11.3% (SD = 9.8%) and 73.4% (SD = 2.3%), respectively (p < 0.0001).

引用

页码：101 / 106

页数：6

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