Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment

被引：46

作者：

Becker, Pamela S. ^{[1
]}

机构：

[1] Univ Washington, Div Hematol, Inst Stem Cell & Regenerat Med, Seattle, WA 98109 USA

来源：

SCIENTIFIC WORLD JOURNAL | 2012年

关键词：

ACUTE MYELOGENOUS LEUKEMIA; MEDIATED DRUG-RESISTANCE; MINIMAL RESIDUAL DISEASE; STEM-CELLS; STROMAL CELLS; STEM/PROGENITOR CELLS; CXCR4; AML; EXPRESSION; CHEMOTHERAPY;

D O I：

10.1100/2012/856467

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Acute myeloid leukemia (AML) cells home to the endosteal region of the bone marrow. They interact with bone marrow stromal components including extracellular matrix proteins, glycosaminoglycans, and stromal cells, by which they derive proliferative and growth inhibitory signals. Furthermore, adhesion to marrow stroma confers chemotherapy drug resistance and thereby promotes leukemia survival. A subpopulation of the leukemic blasts, known as leukemia stem cells, that are capable of propagating the leukemia, remain sheltered in the bone marrow microenvironment, exhibit resistance to chemotherapy, and serve as the origin of relapse after a variable period of remission. Detachment of these cells from the bone marrow in combination with chemotherapy may improve the outcome of therapy for AML.

引用

页数：4

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