Hepatic Stimulator Substance Alleviates Toxin-Induced and Immune-Mediated Liver Injury and Fibrosis in Rats

被引：13

作者：

Yi, Xuerui ^{[1
]}

Song, Ming ^{[2
]}

Yuan, Youcheng ^{[1
]}

Zhang, Xinrui ^{[3
]}

Chen, Wenyin ^{[1
]}

Li, Jin ^{[3
]}

Tong, Minghua ^{[1
]}

Liu, Guangze ^{[1
]}

You, Song ^{[2
]}

Kong, Xiangping ^{[1
]}

机构：

[1] Guangzhou 458 Hosp, Ctr Infect Dis, Key Lab Liver Dis, Guangzhou 510600, Guangdong, Peoples R China

[2] Shenyang Pharmaceut Univ, Inst Life Sci & Biopharmaceut, Shenyang 110016, Liaoning, Peoples R China

[3] So Med Univ, Guangzhou 510515, Guangdong, Peoples R China

来源：

DIGESTIVE DISEASES AND SCIENCES | 2012年 / 57卷 / 08期

关键词：

Hepatic stimulator substance; Liver fibrosis; Carbon tetrachloride; Porcine-serum; Hepatic stellate cell; Transforming growth factor-beta 1; MITOCHONDRIAL PERMEABILITY TRANSITION; STELLATE CELLS; PARTIAL-HEPATECTOMY; PORCINE-SERUM; GROWTH-FACTOR; ANIMAL-MODEL; TGF-BETA; REGENERATION; FIBROGENESIS; MECHANISMS;

D O I：

10.1007/s10620-012-2168-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Liver fibrosis is a common scarring response to chronic liver injury. It is a precursor to cirrhosis and liver carcinoma. Hepatic stimulator substance (HSS), a known liver-specific but species-nonspecific growth factor, has been shown to protect hepatocytes from various toxins. We have investigated the effects of HSS therapy on carbon tetrachloride (CCl4)-induced and porcine-serum-mediated hepatic injury and fibrosis. We hypothesize that HSS might attenuate liver injury and fibrosis by suppressing oxidative stress, down-regulating profibrogenic factors, and blocking HSCs activation. This report demonstrated that HSS therapy diminished alpha-smooth muscle actin expression, decreased intrahepatic reactive oxygen species (ROS) level, and down-regulated transforming growth factor (TGF)-beta 1, platelet-derived growth factor (PDGF)-BB, and tissue inhibitor of metalloproteinase (TIMP)-1 expression. In addition, HSS treatment significantly protected the liver from injury by improving liver function tests and histological architecture of the liver. These results provided novel insights into the mechanisms of HSS in the protection of the liver. Our results suggested that HSS might be a therapeutic antifibrotic agent for the treatment of liver fibrosis.

引用

页码：2079 / 2087

页数：9

共 43 条

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