The dynamics of plasma transforming growth factor beta 1 (TGF-β1) level during radiotherapy with or without simultaneous chemotherapy in advanced head and neck cancer

To assess the plasma TGF-beta1 level during radio(chemo)therapy and to test the predictive power of TGF-beta1 for treatment response in patients with advanced head and neck cancer. Twenty nine patients with advanced head and neck cancer were treated with curative radio(chemo)therapy. Plasma TGF-beta1 level was established at the beginning, in the middle and at the end of the therapy. The dynamics of the TGF-beta1 level was assessed separately for patients with and without chemotherapy. Treatment response was correlated to the TGF-beta1 Level. Eighteen patients achieved complete remission, eight partial remission and three patients progressed. Patients treated with radiotherapy had significantly higher initial plasma TGF-beta1 level compared to radiochemotherapy patients (p = 0.044). During the treatment, there was a significant decrease in patients treated with radiochemotherapy (p = 0.008) but not in radiotherapy patients (p = 0.34). Tumor burden did not correlate with plasma TGF-beta1 level (p = 0.07). TGF-beta1 has no predictive value for treatment response (CR vs. PR and PD, p = 0.12). The combination of radiotherapy and chemotherapy significantly decreases plasma TGF-beta1 level in patients with advanced head and neck cancer. Treatment response cannot be predicted using TGF-beta1. (C) 2004 Elsevier Ltd. All rights reserved.