Acute psychological stress decreases plasma tissue plasminogen activator (tPA) and tissue plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) complexes in cardiac patients

被引:19
作者
Hevey, D [1 ]
McGee, HM
Fitzgerald, D
Horgan, JH
机构
[1] Beaumont Hosp, Dept Cardiol, Dublin 9, Ireland
[2] Royal Coll Surg Ireland, Dept Psychol, Hlth Serv Res Ctr, Dublin 2, Ireland
[3] Royal Coll Surg Ireland, Dept Clin Pharmacol, Dublin 2, Ireland
关键词
psychological stress; tissue plasminogen activator; plasminogen activator inhibitor-1; atherosclerosis;
D O I
10.1007/s004210000299
中图分类号
Q4 [生理学];
学科分类号
071003 [生理学];
摘要
Tissue plasminogen activator (tPA) promotes fibrinolysis and impaired fibrinolysis is associated with atherosclerosis and thrombosis. Plasminogen activator inhibitor-1 (PAI-1) inhibits t-PA expression. The effects of acute laboratory stressors on tPA and tPA/PAI-1 complexes were assessed in a sample of 11 cardiac patients. Participants were randomly assigned to either a stress or relaxation condition at time 1, and the alternative condition at time 2. Blood samples were taken before (pre) and after (post) each session and participants completed a battery of psychological questionnaires. Two-way repeated-measures analysis of variance revealed a statistically significant decrease in tPA (P = 0.01) and tPA-PAI-1 complexes (P = 0.04) during the mental stress condition. Anger-in had a strong relationship to decreases in tPA/PAI-1 levels in the stress condition (r = 0.68, P < 0.05). Relaxation had no significant effect on tPA and tPA/PAI-1 levels. These data suggest that decreased fibrinolysis mediates the relationship between mental stress and atherosclerosis.
引用
收藏
页码:344 / 348
页数:5
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