Stratifying Patients With Stroke in Trials That Target Brain Repair

被引：39

作者：

Cramer, Steven C. ^{[1
]}

机构：

[1] Univ Calif Irvine, Med Ctr, Orange, CA 92868 USA

来源：

STROKE | 2010年 / 41卷 / 10期

关键词：

stroke; treatment; recovery; repair; stratify; MOTOR IMPAIRMENT; CLINICAL-TRIALS; RECOVERY; REHABILITATION; INJURY; CORTEX; CONNECTIVITY; ACTIVATION; MECHANISMS; PLASTICITY;

D O I：

10.1161/STROKEAHA.110.595165

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

A number of therapies are emerging that have the potential to reduce poststroke disability by promoting repair. Careful evaluation of patients with stroke might help distinguish those who are most likely to respond to a restorative therapy from those who lack biological substrate needed to achieve gains. Potential approaches to such stratification are considered, including measures of brain injury or of poststroke brain function. (Stroke. 2010;41[suppl 1]:S114-S116.)

引用

收藏

页码：S114 / S116

页数：3

相关论文

共 33 条

[1]

Neuroimaging in stroke recovery: A position paper from the First International Workshop on Neuroimaging and Stroke Recovery [J].

Baron, JC ;

Black, SE ;

Butler, AJ ;

Carey, J ;

Chollet, F ;

Cohen, LG ;

Corbetta, M ;

Cramer, SC ;

Dobkin, BH ;

Frackowiak, R ;

Heiss, WD ;

Johnsen-Berg, H ;

Krakauer, JW ;

Lazar, RM ;

Lennihan, LL ;

Loubinoux, I ;

Marshall, RS ;

Matthews, P ;

Mohr, JP ;

Nelles, G ;

Pascual-Leone, A ;

Pomeroy, V ;

Rijntjes, M ;

Rossine, PM ;

Rothwell, JC ;

Seitz, RJ ;

Small, SL ;

Sunderland, A ;

Ward, NS ;

Weiller, C ;

Wise, RJS .

CEREBROVASCULAR DISEASES, 2004, 18 (03) :260-267

[2]

The relationship between motor deficit and hemisphere activation balance after stroke: A 3T fMRI study [J].

Calautti, Cinzia ;

Naccarato, Mareello ;

Jones, Peter S. ;

Sharma, Nikhil ;

Day, Diana D. ;

Carpenter, Adrian T. ;

Bullmore, Edward T. ;

Warburton, Elizabeth A. ;

Baron, Jean-Claude .

NEUROIMAGE, 2007, 34 (01) :322-331

[3]

A PET follow-up study of recovery after stroke in acute aphasics [J].

Cappa, SF ;

Perani, D ;

Grassi, F ;

Bressi, S ;

Alberoni, M ;

Franceschi, M ;

Bettinardi, V ;

Todde, S ;

Fazio, F .

BRAIN AND LANGUAGE, 1997, 56 (01) :55-67

[4]

Growth-associated gene expression after stroke: Evidence for a growth-promoting region in peri-infarct cortex [J].

Carmichael, ST ;

Archibeque, I ;

Luke, L ;

Nolan, T ;

Momiy, J ;

Li, SL .

EXPERIMENTAL NEUROLOGY, 2005, 193 (02) :291-311

[5]

Improved understanding of cortical injury by incorporating measures of functional anatomy [J].

Crafton, KR ;

Mark, AN ;

Cramer, SC .

BRAIN, 2003, 126 :1650-1659

[6]

Repairing the human brain after stroke. II. Restorative therapies [J].

Cramer, Steven C. .

ANNALS OF NEUROLOGY, 2008, 63 (05) :549-560

[7]

Predicting functional gains in a stroke trial [J].

Cramer, Steven C. ;

Parrish, Todd B. ;

Levy, Robert M. ;

Stebbins, Glenn T. ;

Ruland, Sean D. ;

Lowry, David W. ;

Trouard, Theodore P. ;

Squire, Scott W. ;

Weinand, Martin E. ;

Savage, Cary R. ;

Wilkinson, Steven B. ;

Juranek, Jenifer ;

Leu, Szu-Yun ;

Himes, David M. .

STROKE, 2007, 38 (07) :2108-2114

[8]

The case for modality-specific outcome measures in clinical trials of stroke recovery-promoting agents [J].

Cramer, Steven C. ;

Koroshetz, Walter J. ;

Finklestein, Seth P. .

STROKE, 2007, 38 (04) :1393-1395

[9]

The Beta-hCG plus Erythropoietin in Acute Stroke (BETAS) Study A 3-Center, Single-Dose, Open-Label, Noncontrolled, Phase IIa Safety Trial [J].

Cramer, Steven C. ;

Fitzpatrick, Camille ;

Warren, Michael ;

Hill, Michael D. ;

Brown, David ;

Whitaker, Laura ;

Ryckborst, Karla J. ;

Plon, Lawrence .

STROKE, 2010, 41 (05) :927-931

[10]

Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after stroke [J].

Dong, Yun ;

Dobkin, Bruce H. ;

Cen, Steven Y. ;

Wu, Allan D. ;

Winstein, Carolee J. .

STROKE, 2006, 37 (06) :1552-1555

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