Spared anterograde memory for shock-probe fear conditioning after inactivation of the amygdala

被引:15
作者
Lehmann, H [1 ]
Treit, D
Parent, MB
机构
[1] Concordia Univ, Ctr Studies Behav Neurobiol, Montreal, PQ H4B 1R6, Canada
[2] Univ Alberta, Dept Psychol, Edmonton, AB T6G 2E9, Canada
[3] Georgia State Univ, Dept Psychol, Atlanta, GA 30303 USA
关键词
D O I
10.1101/lm.54103
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous Studies have shown that amygdala lesions impair avoidance of an electrified probe. This finding has been interpreted as indicating that amygdala lesions reduce fear. It is unclear, however, whether amygdala-lesioned rats learn that the probe is associated with shock. If the lesions prevent the formation of this association, then pretraining reversible inactivation of the amygdala should impair both acquisition and retention performance. To test this hypothesis, the amygdala was inactivated (tetrodotoxin; TTX; I ng/side) before a shock-probe acquisition session, and retention was tested 4 d later. The data indicated that, compared with rats infused with vehicle, rats infused with TTX received more shocks during the acquisition session, but more importantly, were not impaired on the retention test. In Experiment 2, we assessed whether the spared memory on the retention test was caused by overtraining during acquisition. We used the same procedure as in Experiment 1, with the exception that the number of shocks the rats received during the acquisition session was limited to four. Again the data indicated that amygdala inactivation did not impair performance on the retention test. These results indicate that amygdala inactivation does not prevent the formation of an association between the shock and the probe and that shock-probe deficits during acquisition likely reflect the amygdala's involvement in other processes.
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页码:261 / 269
页数:9
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