Diagnostic capabilities of frequency-doubling technology, scanning laser polarimetry, and nerve fiber layer photographs to distinguish glaucomatous damage

被引:82
作者
Paczka, JA
Friedman, DS
Quigley, HA
Barron, Y
Vitale, S
机构
[1] Johns Hopkins Hosp, Wilmer Ophthalmol Inst, Dana Ctr Prevent Ophthalmol, Baltimore, MD 21287 USA
[2] Univ Guadalajara, CUCS, Inst Oftalmol & Ciencias Visuales, Guadalajara, Jalisco, Mexico
[3] Johns Hopkins Hosp, Wilmer Ophthalmol Inst, Glaucoma Serv, Baltimore, MD 21287 USA
关键词
D O I
10.1016/S0002-9394(00)00644-9
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE: To investigate the ability of three diagnostic tests: frequency-doubling technology (FDT), scanning laser polarimetry (GDx), and nerve fiber layer (NFL) photographs to distinguish normal from glaucomatous eyes. METHODS: Data were obtained in a cross-sectional, hospital clinic-based study, including one eye from each of 253 persons older than 40 years (68 normal, 94 glaucoma suspects and 91 glaucoma patients), We performed a comprehensive ocular examination, as well as static automated perimetry (Humphrey 24-2), screening FDT, GDx, optic nerve stereoscopic photographs and high-contrast Nn photographs. RESULTS: The following were significantly different for glaucomatous patients compared with suspects and normals: mean values of mean deviation (MD, Humphrey 24-2) and corrected pattern standard deviation (CPSD), 11 GDx indices, mean FDT testing time and missed points, and Nn graded defects (ANOVA, Mantel-Haenszel test; p = 0.0001). Using Humphrey 24-2 test results and clinical assessment as the defining features of glaucoma, we found that the optimal mix of sensitivity and specificity values were 84% and 100% for FDT (presence of any defect); 62% and 96% for GDx (The Number, cut-off value of 27); and, 95% and 82% for NFL photographs (presence of any abnormality). FDT testing took the least time to be administered. CONCLUSIONS: The FDT had the best diagnostic performance. Neural network analysis of GDx data outperformed other elements of its software. (Am J Ophthalmol 2001;131:188-197. (C) 2001 by Elsevier Science Inc. All rights reserved).
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页码:188 / 197
页数:10
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