Studies into diastereoselective Dotz benzannulations for the synthesis of axially chiral biaryls

被引：11

作者：

Anderson, JC ^{[1
]}

Cran, JW

King, NP

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 42期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.tetlet.2003.08.096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of racemic chiral ortho substituents on 1-phenythex-1-yne have been found to control the atroposelective formation of a biaryl from Dotz benzannulation with pentacarbonyl(methoxyphenylmethylene)chromium(0). The results show there is a subtle balance between the chiral ortho substituent controlling atroposelectivity with a dr 3-5:1 and allowing benzannulation to proceed in yields of 44-67%. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：7771 / 7774

页数：4

共 38 条

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