Antiprotozoal activity of the constituents of Teloxys graveolens

被引：36

作者：

Calzada, F

Velázquez, C

Cedillo-Rivera, R

Esquivel, B

机构：

[1] IMSS, Ctr Med Nacl Siglo 21, Hosp Pediat, Unidad Invest Med Farmacol Prod Nat, Mexico City 06725, DF, Mexico

[2] IMSS, Ctr Med Nacl Siglo 21, Hosp Pediat, Unidad Invest Med Enfermedades Infecciosas & Para, Mexico City 06725, DF, Mexico

[3] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

来源：

PHYTOTHERAPY RESEARCH | 2003年 / 17卷 / 07期

关键词：

melilotoside; antiprotozoal activity; Entamoeba histolytica; Giardia lamblia; Teloxys graveolens;

D O I：

10.1002/ptr.1192

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antiprotozoal activity-guided fractionation of a methanol extract of the aerial parts of Teloxys graveolens led to the isolation of one coumarinic acid derivative, melilotoside, and five flavonoids, pinocembrine, pinostrobin, chrysin, narcissin and rutin. Among them, melilotoside exhibited the most potent activity toward Entamoeba histolytica and Giardia lamblia (IC50, 12.5 and 16.8 mug/mL, respectively). Narcissin showed selectivity against E. histolytlica (IC50 17.2 mug/mL). The results support data for the traditional use of T. graveolens in some gastrointestinal diseases. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：731 / 732

页数：2

共 10 条

[1] Antiamoebic and antigiardial activity of plant flavonoids [J].

Calzada, F ;

Meckes, M ;

Cedillo-Rivera, R .

PLANTA MEDICA, 1999, 65 (01) :78-80

[2] Geranins A and B, new antiprotozoal A-type proanthocyanidins from Geranium niveum [J].

Calzada, F ;

Cerda-García-Rojas, CM ;

Meckes, M ;

Cedillo-Rivera, R ;

Bye, R ;

Mata, R .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (05) :705-709

[3] Antiprotozoal activity of the constituents of Conyxa filaginoides [J].

Calzada, F ;

Cedillo-Rivera, R ;

Mata, R .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (05) :671-673

[4]

CAMACHO MD, 1991, J ETHNOPHARMACOL, V31, P383

[5] Antimicrobial activity of flavonoids in medicinal plants from Tafi del Valle (Tucuman, Argentina) [J].

Hernández, NE ;

Tereschuk, ML ;

Abdala, LR .

JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (1-2) :317-322

[6]

Kapoor K, 1999, INT J CLIN PHARM RES, V19, P83

[7]

MATA R, 1987, PHYTOCHEMISTRY, V26, P191, DOI 10.1016/S0031-9422(00)81509-5

[8] The effects of chrysin and pinostrobin, two flavonoids isolated from Teloxys graveolens leaves, on isolated guinea-pig ileum [J].

Meckes, M ;

Paz, D ;

Acosta, J ;

Mata, R .

PHYTOMEDICINE, 1998, 5 (06) :459-463

[9] SCREENING FOR ANTIMICROBIAL ACTIVITY OF CRUDE DRUG EXTRACTS AND PURE NATURAL-PRODUCTS FROM MEXICAN MEDICINAL-PLANTS [J].

ROJAS, A ;

HERNANDEZ, L ;

PEREDAMIRANDA, R ;

MATA, R .

JOURNAL OF ETHNOPHARMACOLOGY, 1992, 35 (03) :275-283

[10] The flavonoid constituents of two polypodium species (Calaguala) and their effect on the elastase release in human neutrophils [J].

Vasange, M ;

Liu, BL ;

Welch, CJ ;

Rolfsen, WC ;

Bohlin, L .

PLANTA MEDICA, 1997, 63 (06) :511-517

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