Recurring thrombocytopenia associated with structured treatment interruption in patients with human immunodeficiency virus infection

被引：21

作者：

Ananworanich, J

Phanuphak, N

Nuesch, R

Apateerapong, W

Rojnuckarin, P

Ubolyam, S

Phanuphak, P

Ruxrungtham, K

机构：

[1] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok 10330, Thailand

[2] Human Immunodeficiency Virus Netherlands Australi, Bangkok, Thailand

[3] Chulalongkorn Univ, Dept Internal Med, Bangkok, Thailand

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 37卷 / 05期

关键词：

D O I：

10.1086/376989

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a structured treatment interruption (STI) trial, 3 of 23 patients in a CD4 cell count-guided treatment arm developed recurring thrombocytopenia associated with the interruption of antiretroviral therapy. All 3 patients had slightly low or normal platelet counts before initiating antiretroviral therapy. STI may play a role in inducing thrombocytopenia in patients with human immunodeficiency virus infection.

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收藏

页码：723 / 725

页数：3

相关论文

共 19 条

[1] Initial observations on the efficacy of highly active antiretroviral therapy in the treatment of HIV-associated autoimmune thrombocytopenia [J].

Aboulafia, DM ;

Bundow, D ;

Waide, S ;

Bennet, C ;

Kerr, D .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2000, 320 (02) :117-123

[2] KINETIC-STUDIES OF THE MECHANISM OF THROMBOCYTOPENIA IN PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].

BALLEM, PJ ;

BELZBERG, A ;

DEVINE, DV ;

LYSTER, D ;

SPRUSTON, B ;

CHAMBERS, H ;

DOUBROFF, P ;

MIKULASH, K .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (25) :1779-1784

[3]

Brook MG, 1997, GENITOURIN MED, V73, P117

[4] Response of severe HIV-associated thrombocytopenia to highly active antiretroviral therapy including protease inhibitors [J].

Carbonara, S ;

Fiorentino, G ;

Serio, G ;

Maggi, P ;

Ingravallo, G ;

Monno, L ;

Bruno, F ;

Coppola, S ;

Pastore, G ;

Angarano, G .

JOURNAL OF INFECTION, 2001, 42 (04) :251-256

[5] Characterization of HIV-1-specific antibodies and HIV-1-crossreactive antibodies to platelets in HIV-1-infected haemophiliac patients [J].

Chia, WK ;

Blanchette, V ;

Mody, M ;

Wright, JF ;

Freedman, J .

BRITISH JOURNAL OF HAEMATOLOGY, 1998, 103 (04) :1014-1022

[6] Ineffective platelet production in thrombocytopenic human immunodeficiency virus-infected patients [J].

Cole, JL ;

Marzec, UM ;

Gunthel, CJ ;

Karpatkin, S ;

Worford, L ;

Sundell, IB ;

Lennox, JL ;

Nichol, JL ;

Harker, LA .

BLOOD, 1998, 91 (09) :3239-3246

[7] Hematologic complications of human immunodeficiency virus infection and the acquired immunodeficiency syndrome [J].

Coyle, TE .

MEDICAL CLINICS OF NORTH AMERICA, 1997, 81 (02) :449-+

[8]

FINAZZI G, 1990, EUR J HAEMATOL, V45, P82

[9] THROMBOCYTOPENIA IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS - TREATMENT UPDATE [J].

GLATT, AE ;

ANAUD, A .

CLINICAL INFECTIOUS DISEASES, 1995, 21 (02) :415-423

[10] AN EVALUATION OF A SOLID-PHASE RED-CELL ADHERENCE TEST FOR DETECTING PLATELET-ASSOCIATED IGG IN IMMUNE THROMBOCYTOPENIA [J].

JONES, CD ;

GOULD, LM ;

LEE, S .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1990, 93 (04) :552-554