Expression of the extra-large G protein α-subunit XLαs in neuroepithelial cells and young neurons during development of the rat nervous system

被引：24

作者：

Pasolli, HA

Huttner, WB

机构：

[1] Heidelberg Univ, Dept Neurobiol, Interdisciplinary Ctr Neurosci, D-69120 Heidelberg, Germany

[2] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

来源：

NEUROSCIENCE LETTERS | 2001年 / 301卷 / 02期

关键词：

G protein; nervous system; pituitary; rat embryo; development;

D O I：

10.1016/S0304-3940(01)01620-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

XL alphas ('extra large' alpha) is a 78 kDa splice variant of the alpha -subunit of the heterotrimeric G protein, Gs (Nature 372 (1994) 804). Prompted by its neuroendocrine-specific tissue distribution in the adult (J. Biol, Chem. 275 (2000) 33622) and its ability to activate adenylyl cyclase (J. Biol. Chem. 275 (2000) 33633), we investigated the expression of XL alphas in the developing rat nervous system using immunofluorescence. Remarkably, XL alphas expression in the neural tube was found to begin at the onset of neurogenesis, being observed in a subset of mitotic neuroepithelial cells as well as in young neurons. At later developmental stages, XL alphas was associated with a subset of neurons in certain regions of the nervous system such as diencephalon, midbrain, hindbrain, spinal cord and sympathetic trunk. These results suggest a role of XL alphas in neuronal differentiation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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页码：119 / 122

页数：4

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