Competitive intramolecular nucleophilic aromatic substitution: A new route to coumarins

被引：5

作者：

Alonso, C ^{[1
]}

Olmstead, MM ^{[1
]}

Nantz, MH ^{[1
]}

Kurth, MJ ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 07期

关键词：

D O I：

10.1039/b009172n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-Hydroxy-3-(2'-pyridyl)coumarins (4) (R=6-Cl, H, 6-NO2, 8-NO2) were prepared in moderate to good yields by the intramolecular nucleophilic aromatic substitution reaction of beta -ketoesters (I) in refluxing xylenes; evidence for the reversible formation of benzo[c]quinolizinium III from I (X = 4 -Cl), with eventual formation of 4 (R = 6-Cl), is also presented.

引用

页码：639 / 640

页数：2

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