Synthesis and bioactivity of new antineoplastic terpenylquinones

被引：23

作者：

Gordaliza, M ^{[1
]}

delCorral, JMM ^{[1
]}

Castro, MA ^{[1
]}

Mahiques, MM ^{[1
]}

GarciaGravalos, MD ^{[1
]}

SanFeliciano, A ^{[1
]}

机构：

[1] PHARMAMAR SA,E-28760 MADRID,SPAIN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 15期

关键词：

D O I：

10.1016/0960-894X(96)00326-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several monoterpenylquinones have been prepared and evaluated for their cytotoxic activity against four cell lines cultures. The size of the quinone fragment is important for the activity, being the naphtalene derivatives the most potent compounds tested. The presence of substituents on the quinone ring decreases the potency but increases the selectivity. Copyright (C) 1996 Elsevier Science Ltd

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页码：1859 / 1864

页数：6

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