Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy

被引：56

作者：

Amary, M. Fernanda ^{[1
,2
]}

Ye, Hongtao ^{[1
]}

Berisha, Fitim ^{[1
]}

Khatri, Bhavisha ^{[1
]}

Forbes, Georgina ^{[1
]}

Lehovsky, Katie ^{[1
]}

Frezza, Anna M. ^{[2
,3
]}

Behjati, Sam ^{[4
]}

Tarpey, Patrick ^{[4
]}

Pillay, Nischalan ^{[1
,2
]}

Campbell, Peter J. ^{[4
]}

Tirabosco, Roberto ^{[1
]}

Presneau, Nadege ^{[2
]}

Strauss, Sandra J. ^{[2
,3
]}

Flanagan, Adrienne M. ^{[1
,2
]}

机构：

[1] Royal Natl Orthopaed Hosp NHS Trust, London Sarcoma Serv, Stanmore HA7 4LP, Middx, England

[2] UCL, Inst Canc, London WC1E 6BT, England

[3] Univ Coll London Hosp Fdn Trust, London Sarcoma Serv, London NW1 2PG, England

[4] Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, Cambs, England

来源：

CANCER MEDICINE | 2014年 / 3卷 / 04期

基金：

英国惠康基金;

关键词：

Amplification; FGFR; FGFR1; FISH; genetics; osteosarcoma; polysomy; COMPARATIVE GENOMIC HYBRIDIZATION; SQUAMOUS-CELL CARCINOMA; FGFR1; AMPLIFICATION; BREAST; SURVIVAL; EXPRESSION; FREQUENCY; SUBTYPE; BONE;

D O I：

10.1002/cam4.268

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Osteosarcoma, the most common primary bone sarcoma, is a genetically complex disease with no widely accepted biomarker to allow stratification of patients for treatment. After a recent report of one osteosarcoma cell line and one tumor exhibiting fibroblastic growth factor receptor 1 (FGFR1) gene amplification, the aim of this work was to assess the frequency of FGFR1 amplification in a larger cohort of osteosarcoma and to determine if this biomarker could be used for stratification of patients for treatment. About 352 osteosarcoma samples from 288 patients were analyzed for FGFR1 amplification by interphase fluorescence in situ hybridization. FGFR1 amplification was detected in 18.5% of patients whose tumors revealed a poor response to chemotherapy, and no patients whose tumors responded well to therapy harbored this genetic alteration. FGFR1 amplification is present disproportionately in the rarer histological variants of osteosarcoma. This study provides a rationale for inclusion of patients with osteosarcoma in clinical trials using FGFR kinase inhibitors.

引用

页码：980 / 987

页数：8

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