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The role of microbial biofilms in prosthetic joint infections

被引：338
作者：
Gbejuade, Herbert O. [1 ,2 ]
Lovering, Andrew M. [3 ]
Webb, Jason C. [1 ,2 ]
机构：
[1] Southmead Hosp, Avon Orthoped Ctr, Bristol, Avon, England
[2] Univ Bristol, Bristol, Avon, England
[3] Southmead Hosp, Dept Microbiol, Bristol, Avon, England
来源：
ACTA ORTHOPAEDICA | 2015年 / 86卷 / 02期
关键词：
TOTAL HIP-ARTHROPLASTY; POLYSACCHARIDE INTERCELLULAR ADHESIN/HEMAGGLUTININ; STAPHYLOCOCCUS-AUREUS BIOFILMS; LASER-SCANNING MICROSCOPY; REVISION TOTAL HIP; PSEUDOMONAS-AERUGINOSA; DNA RELEASE; ANTIMICROBIAL PEPTIDES; BACTERIAL BIOFILMS; EXTRACELLULAR DNA;
D O I：
10.3109/17453674.2014.966290
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
100224 [整形外科学];
摘要：
Prosthetic joint infection (PJI) still remains a significant problem. In line with the forecasted rise in joint replacement procedures, the number of cases of PJI is also anticipated to rise. The formation of biofilm by causative pathogens is central to the occurrence and the recalcitrance of PJI. The subject of microbial biofilms is receiving increasing attention, probably as a result of the wide acknowledgement of the ubiquity of biofilms in the natural, industrial, and clinical contexts, as well as the notorious difficulty in eradicating them. In this review, we discuss the pertinent issues surrounding PJI and the challenges posed by biofilms regarding diagnosis and treatment. In addition, we discuss novel strategies of prevention and treatment of biofilm-related PJI.
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页码：147 / 158
页数：12
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