Novel neural modulators

被引：424

作者：

Boehning, D

Snyder, SH

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2003年 / 26卷

关键词：

serine racemase; nitric oxide synthase; heme oxygenase; carbon monoxide; hydrogen sulfide;

D O I：

10.1146/annurev.neuro.26.041002.131047

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The discovery that nitric oxide (NO) is produced by neurons and regulates synaptic activity has challenged the definition of a neurotransmitter. NO is not stored in synaptic vesicles and does not act at conventional receptors on the surface of adjacent neurons. The toxic gases carbon monoxide (CO) and hydrogen sulfide (H2S) are also produced by neurons and modulate synaptic activity. D-serine synthesis and release by astrocytes as an endogenous ligand for the "glycine" site of N-methyl D-aspartate (NNMA) receptors defy the concept that a neurotransmitter must be synthesized by neurons. We review the properties of these "atypical" neural modulators.

引用

页码：105 / 131

页数：27

共 162 条

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