Nephrectomy decreases amylin and pramlintide clearance in rats

被引：14

作者：

Vine, W ^{[1
]}

Smith, P ^{[1
]}

LaChappell, R ^{[1
]}

Blase, E ^{[1
]}

Lumpkin, R ^{[1
]}

Young, A ^{[1
]}

机构：

[1] Amylin Pharmaceut Inc, San Diego, CA 92121 USA

来源：

HORMONE AND METABOLIC RESEARCH | 1998年 / 30卷 / 08期

关键词：

amylin; nephrectomy; pharmacokinetics; pharmacodynamics; pramlintide;

D O I：

10.1055/s-2007-978923

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amylin is a 37 amino acid hormone, co-secreted with insulin from the pancreatic beta-cell in response to nutrient stimuli. Because the human amylin analog, pramlintide, is being tested in patients with diabetes mellitus, a known risk factor for nephropathy, we examined the role of the kidney on amylin and pramlintide metabolism and action in functionally nephrectomized rats. Nephrectomy markedly altered amylin metabolism: it increased incremental area under the plasma amylin concentration curve 3.6-fold (P<0.001) and increased the elimination half-life from 17 +/- 1 to 26 +/- 2 minutes (P<0.01) after subcutaneous injection of 100 mu g amylin. Nephrectomy decreased plasma amylin clearance from 20.3 +/- 1.1 to 7.9 +/- 0.4 mL/min (P<0.0001). Thus, at these doses in the rat, the kidney is important for metabolizing amylin and pramlintide.

引用

页码：514 / 517

页数：4

共 25 条

[1]

Ardaillou R, 1980, Adv Nephrol Necker Hosp, V9, P247

[2] METABOLIC CLEARANCE RATE OF RADIOIODINATED HUMAN CALCITONIN IN MAN [J].