Pulmonary hypertension: NO therapy?

被引：7

作者：

Adnot, S

Raffestin, B

机构：

来源：

THORAX | 1996年 / 51卷 / 07期

关键词：

pulmonary hypertension; nitric oxide; endothelium;

D O I：

10.1136/thx.51.7.762

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Endothelium-derived nitric oxide (NO) is a powerful pulmonary vasodilator which also prevents adhesion and aggregation of platelets, controls growth of smooth muscle, and influences the expression of growth promoting and vasoactive substances. Impaired endothelial NO production contributes to pulmonary vasoconstriction and vascular remodelling in several forms of pulmonary hypertension. Exogenous NO gas delivered via the airspaces is a selective pulmonary vasodilator now used as treatment in various lung disorders.

引用

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页码：762 / 764

页数：3

相关论文

共 13 条

[1] HEMODYNAMIC AND GAS-EXCHANGE RESPONSES TO INFUSION OF ACETYLCHOLINE AND INHALATION OF NITRIC-OXIDE IN PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG-DISEASE AND PULMONARY-HYPERTENSION [J].

ADNOT, S ;

KOUYOUMDJIAN, C ;

DEFOUILLOY, C ;

ANDRIVET, P ;

SEDIAME, S ;

HERIGAULT, R ;

FRATACCI, MD .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (02) :310-316

[2] LOSS OF ENDOTHELIUM-DEPENDENT RELAXANT ACTIVITY IN THE PULMONARY CIRCULATION OF RATS EXPOSED TO CHRONIC HYPOXIA [J].

ADNOT, S ;

RAFFESTIN, B ;

EDDAHIBI, S ;

BRAQUET, P ;

CHABRIER, PE .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (01) :155-162

[3] NITRIC-OXIDE DECREASES CYTOKINE-INDUCED ENDOTHELIAL ACTIVATION - NITRIC-OXIDE SELECTIVELY REDUCES ENDOTHELIAL EXPRESSION OF ADHESION MOLECULES AND PROINFLAMMATORY CYTOKINES [J].

DECATERINA, R ;

LIBBY, P ;

PENG, HB ;

THANNICKAL, VJ ;

RAJAVASHISTH, TB ;

GIMBRONE, MA ;

SHIN, WS ;

LIAO, JK .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (01) :60-68

[4] CHRONIC NITRIC-OXIDE INHIBITION IN-UTERO PRODUCES PERSISTENT PULMONARY-HYPERTENSION IN NEWBORN LAMBS [J].

FINEMAN, JR ;

WONG, J ;

MORIN, FC ;

WILD, LM ;

SOIFER, SJ .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (06) :2675-2683

[5] REDUCED EXPRESSION OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE IN THE LUNGS OF PATIENTS WITH PULMONARY-HYPERTENSION [J].

GIAID, A ;

SALEH, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (04) :214-221

[6] NITRIC-OXIDE REGULATES THE EXPRESSION OF VASOCONSTRICTORS AND GROWTH-FACTORS BY VASCULAR ENDOTHELIUM UNDER BOTH NORMOXIA AND HYPOXIA [J].

KOUREMBANAS, S ;

MCQUILLAN, LP ;

LEUNG, GK ;

FALLER, DV .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (01) :99-104

[7] CONTINUOUS INHALATION OF NITRIC-OXIDE PROTECTS AGAINST DEVELOPMENT OF PULMONARY-HYPERTENSION IN CHRONICALLY HYPOXIC RATS [J].

KOUYOUMDJIAN, C ;

ADNOT, S ;

LEVAME, M ;

EDDAHIBI, S ;

BOUSBAA, H ;

RAFFESTIN, B .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (02) :578-584

[8]

McQuillan Lynda P., 1994, American Journal of Physiology, V267, pH1921

[9]

MONCADA S, 1991, PHARMACOL REV, V43, P109

[10] PROSTACYCLIN AND ACETYLCHOLINE AS SCREENING AGENTS FOR ACUTE PULMONARY VASODILATOR RESPONSIVENESS IN PRIMARY PULMONARY-HYPERTENSION [J].

PALEVSKY, HI ;

LONG, W ;

CROW, J ;

FISHMAN, AP .

CIRCULATION, 1990, 82 (06) :2018-2026