Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

被引：54

作者：

Rijken, Marcus J. ^{[1
]}

Boel, Machteld E. ^{[1
]}

Russell, Bruce ^{[2
]}

Imwong, Mallika ^{[3
]}

Leimanis, Mara L. ^{[1
]}

Phyo, Aung Pyae ^{[1
]}

Muehlenbachs, Atis ^{[4
]}

Lindegardh, Niklas ^{[5
]}

McGready, Rose ^{[1
,5
]}

Renia, Laurent ^{[2
]}

Snounou, Georges ^{[2
,6
,7
]}

Singhasivanon, Pratap

Nosten, Francois ^{[1
,5
]}

机构：

[1] Shoklo Malaria Res Unit, Tak 63110, Thailand

[2] ASTAR, Lab Malaria Immunobiol, Singapore Immunol Network, Biopolis, Singapore, Singapore

[3] Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok 10400, Thailand

[4] Univ Washington, Seattle, WA 98195 USA

[5] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, CCVTM, Oxford OX3 7LJ, England

[6] Univ Paris 06, INSERM, UMR S 945, F-75013 Paris, France

[7] Univ Paris 06, Fac Med Pitie Salpetriere, F-75013 Paris, France

来源：

MALARIA JOURNAL | 2011年 / 10卷

基金：

英国惠康基金;

关键词：

IN-VITRO SENSITIVITY; PLASMODIUM-VIVAX; AMODIAQUINE; INFECTION; EFFICACY; MYANMAR;

D O I：

10.1186/1475-2875-10-113

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.

引用

页数：5

共 19 条

[1] Resistance to Therapies for Infection by Plasmodium vivax [J].