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Ghrelin: An orexigenic and somatotrophic signal from the stomach

被引：320
作者：
Inui, A [1 ]
机构：
[1] Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Diabet Digest & Kidney Dis,Chuo Ku, Kobe, Hyogo 6500017, Japan
来源：
NATURE REVIEWS NEUROSCIENCE | 2001年 / 2卷 / 08期
关键词：
D O I：
10.1038/35086018
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach and is released in response to fasting. Ghrelin is structurally related to motilin and, together, they represent a novel family of gut-brain regulatory peptides. In addition to having a powerful effect on the secretion of growth hormone, ghrelin stimulates energy production and signals directly to the hypothalamic regulatory nuclei that control energy homeostasis. The study of ghrelin has extended our understanding of how growth is controlled, and has shown that the stomach is an important component of this system.
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页码：551 / 560
页数：10
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