Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function

被引：207

作者：

Ohnuma, Kei ^{[1
]}

Dang, Nam H. ^{[2
]}

Morimoto, Chikao ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Minato Ku, Div Clin Immunol,Adv Clin Res Ctr, Tokyo 1088639, Japan

[2] Nevada Canc Inst, Dept Hematol Malignancies, Las Vegas, NV 89135 USA

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 06期

关键词：

D O I：

10.1016/j.it.2008.02.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of CD26 in human T cell biology is puzzling. Despite being extensively characterized, it has been called 'a moonlighting protein' since it has multifunctional effects, but a definitive native ligand has not been identified. We summarize the current knowledge on the molecular mechanisms of CD26-mediated T cell costimulation and immune regulation. Work identifying a ligand for CD26 and elucidating the proximal signaling events associated with CD26-mediated T cell costimulation is also described. Finally, we discuss the involvement of CD26 in various pathophysiologic states as well as its suitability as a potential therapeutic target in selected immune diseases.

引用

页码：295 / 301

页数：7

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