Genetic, biochemical and structural approaches to talin function

被引：36

作者：

Critchley, DR ^{[1
]}

机构：

[1] Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

关键词：

actin cytoskeleton; integrin; talin; vinculin-binding site;

D O I：

10.1042/BST0331308

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytoskeletal protein talin plays a key role in coupling the integrin family of cell adhesion molecules to the actin cytoskeleton. in this paper I present a brief review on talin and summarize our recent studies, in which we have taken both genetic and structural approaches to further elucidate the function of the protein.

引用

页码：1308 / 1312

页数：5

共 63 条

[1] ALBIGESRIZO C, 1995, J CELL SCI, V108, P3317
[2] Structural basis for vinculin activation at sites of cell adhesion
Bakolitsa, C
Cohen, DM
Bankston, LA
Bobkov, AA
Cadwell, GW
Jennings, L
Critchley, DR
Craig, SW
Liddington, RC
[J]. NATURE, 2004, 430 (6999) : 583 - 586
[3] Phosphatidylinositol phosphate kinase type 1γ and β1-Integrin cytoplasmic domain bind to the same region in the talin FERM domain
Barsukov, IL
Prescot, A
Bate, N
Patel, B
Floyd, DN
Bhanji, N
Bagshaw, CR
Letinic, K
Di Paolo, G
De Camilli, P
Roberts, GCK
Critchley, DR
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (33) : 31202 - 31209
[4] Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix
Bass, MD
Smith, BJ
Prigent, SA
Critchley, DR
[J]. BIOCHEMICAL JOURNAL, 1999, 341 : 257 - 263
[5] Further characterization of the interaction between the cytoskeletal proteins talin and vinculin
Bass, MD
Patel, B
Barsukov, IG
Fillingham, IJ
Mason, R
Smith, BJ
Bagshaw, CR
Critchley, DR
[J]. BIOCHEMICAL JOURNAL, 2002, 362 : 761 - 768
[6] Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila
Bécam, IE
Tanentzapf, G
Lepesant, JA
Brown, NH
Huynh, JR
[J]. NATURE CELL BIOLOGY, 2005, 7 (05) : 510 - 516
[7] Talin concentrates to the midbody region during mammalian cell cytokinesis
Bellissent-Waydelich, A
Vanier, MT
Albigès-Rizo, C
Simon-Assmann, P
[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1999, 47 (11) : 1357 - 1367
[8] Crystal structure of human vinculin
Borgon, RA
Vonrhein, C
Bricogne, G
Bois, PRJ
Izard, T
[J]. STRUCTURE, 2004, 12 (07) : 1189 - 1197
[9] Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles
Borowsky, ML
Hynes, RO
[J]. JOURNAL OF CELL BIOLOGY, 1998, 143 (02) : 429 - 442
[10] Talin is essential for integrin function in Drosophila
Brown, NH
Gregory, SL
Rickoll, WL
Fessler, LI
Prout, M
White, RAH
Fristrom, JW
[J]. DEVELOPMENTAL CELL, 2002, 3 (04) : 569 - 579

← 1 2 3 4 5 6 7 →