Determination of fosfomycin in human urine by capillary gas chromatography: Application to clinical pharmacokinetic studies

被引：24

作者：

DiosVieitez, MC ^{[1
]}

Goni, MM ^{[1
]}

Renedo, MJ ^{[1
]}

Fos, D ^{[1
]}

机构：

[1] UNIV NAVARRA,FAC FARM,DEPT FARM & TECNOL FARMACEUT,PAMPLONA 31080,SPAIN

来源：

CHROMATOGRAPHIA | 1996年 / 43卷 / 5-6期

关键词：

gas chromatography; fosfomycin in urine; pharmacokinetics;

D O I：

10.1007/BF02270997

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A capillary gas chromatographic method for the determination of fosfomycin in human urine is described. After dilution of the sample and derivatization, analysis was on a HP-1 capillary column and a flame ionization detector was used to determine the bistrimethylsilyl derivative of fosfomycin. Response was linear in the range 50-5000 mu g mL(-1). The detection limit was about 10 mu g mL(-1). The within and between day coefficients of variation did not exceed 6 %. The method was applied to the determination of fosfomycin in urine samples collected during clinical pharmacokinetic studies.

引用

页码：293 / 295

页数：3

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