GPCR-mediated transactivation of RTKs in the CNS: mechanisms and consequences

被引：103

作者：

Shah, BH ^{[1
]}

Catt, KJ ^{[1
]}

机构：

[1] NICHHD, Endocrinol & Reprod Res Branch, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 01期

关键词：

D O I：

10.1016/j.tins.2003.11.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

G protein-coupled receptors (GPCRs) mediate cellular responses to a diverse array of extracellular messenger molecules. Recent studies have shown that GPCR-mediated signaling pathways include transactivation of receptor tyrosine kinases (RTKs), such as receptors for epidermal growth factor, platelet-derived growth factor, neurotrophins and fibroblast growth factor. Cross-communication between GPCRs and RTKs is a complex process, and utilizes sets of signalling molecules that are primarily determined by cell context and the types of receptors activated. The differential involvement of RTKs and downstream signaling pathways activated in response to GPCR-mediated stimulation elicits a variety of cellular effects during development, proliferation, differentiation, survival, repair and synaptic transmission in the CNS.

引用

页码：48 / 53

页数：6

共 66 条

[1] EPIDERMAL GROWTH-FACTOR SELECTIVELY ENHANCES NMDA RECEPTOR-MEDIATED INCREASE OF INTRACELLULAR CA2+ CONCENTRATION IN RAT HIPPOCAMPAL-NEURONS [J].

ABE, K ;

SAITO, H .

BRAIN RESEARCH, 1992, 587 (01) :102-108

[2] Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy [J].

Asakura, M ;

Kitakaze, M ;

Takashima, S ;

Liao, Y ;

Ishikura, F ;

Yoshinaka, T ;

Ohmoto, H ;

Node, K ;

Yoshino, K ;

Ishiguro, H ;

Asanuma, H ;

Sanada, S ;

Matsumura, Y ;

Takeda, H ;

Beppu, S ;

Tada, M ;

Hori, M ;

Higashiyama, S .

NATURE MEDICINE, 2002, 8 (01) :35-40

[3] The fibroblast growth factor receptor is at the site of convergence between μ-opioid receptor and growth factor signaling pathways in rat C6 glioma cells [J].

Belcheva, MM ;

Haas, PD ;

Tan, Y ;

Heaton, VM ;

Coscia, CJ .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 303 (03) :909-918

[4] Regulation of cell number by MAPK-dependent control of apoptosis: A mechanism for trophic survival signaling [J].

Bergmann, A ;

Tugentman, M ;

Shilo, BZ ;

Steller, H .

DEVELOPMENTAL CELL, 2002, 2 (02) :159-170

[5] MAPK, CREB and zif268 are all required for the consolidation of recognition memory [J].

Bozon, B ;

Kelly, A ;

Josselyn, SA ;

Silva, AJ ;

Davis, S ;

Laroche, S .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2003, 358 (1432) :805-814

[6]

Brodie C, 1999, CELL GROWTH DIFFER, V10, P183

[7] Neuregulin and ErbB receptor signaling pathways in the nervous system [J].

Buonanno, A ;

Fischbach, GD .

CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (03) :287-296

[8] Neurotrophins and their receptors: A convergence point for many signalling pathways [J].

Chao, MV .

NATURE REVIEWS NEUROSCIENCE, 2003, 4 (04) :299-309

[9] The developing synapse: Construction and modulation of synaptic structures and circuits [J].

Cohen-Cory, S .

SCIENCE, 2002, 298 (5594) :770-776

[10] FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition [J].

Cross, MJ ;

Claesson-Welsh, L .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2001, 22 (04) :201-207

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