Aquaporin-2 water channels and vasopressin antagonists in edematous disorders

被引：17

作者：

Schrier, RW ^{[1
]}

Ohara, M ^{[1
]}

Rogachev, B ^{[1
]}

Xu, LM ^{[1
]}

Knotek, M ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA

来源：

MOLECULAR GENETICS AND METABOLISM | 1998年 / 65卷 / 04期

关键词：

D O I：

10.1006/mgme.1998.2765

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In summary, in Fig. 6 is shown that edematous disorders, including cardiac failure, cirrhosis, and pregnancy are associated with arterial underfilling, which stimulates the nonosmotic release of vasopressin with upregulation of AQP2 water channels. The resultant water retention and hyponatremia may be reversed by orally active V2 antagonists.

引用

页码：255 / 263

页数：9

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