Immune responses in the skin in old age

被引：44

作者：

Vukmanovic-Stejic, Milica ^{[1
]}

Rustin, Malcolm H. A. ^{[2
]}

Nikolich-Zugich, Janko ^{[3
,4
]}

Akbar, Arne N. ^{[1
]}

机构：

[1] UCL, Div Infect & Immun, Dept Immunol, London W1T 4JF, England

[2] Royal Free Hosp, Dept Dermatol, London NW3 2QG, England

[3] Univ Arizona, Coll Med, Dept Immunobiol, Tucson, AZ 85719 USA

[4] Univ Arizona, Coll Med, Arizona Ctr Aging, Tucson, AZ 85719 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; DELAYED-TYPE HYPERSENSITIVITY; LANGERHANS CELLS; DENDRITIC CELLS; CONTACT HYPERSENSITIVITY; MEDIATED-IMMUNITY; NURSING-HOME; INNATE; EXHAUSTION; EXPRESSION;

D O I：

10.1016/j.coi.2011.05.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.

引用

页码：525 / 531

页数：7

共 64 条

[1]

Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging [J].

Agius, Elaine ;

Lacy, Katie E. ;

Vukmanovic-Stejic, Milica ;

Jagger, Ann L. ;

Papageorgiou, Anna-Pia ;

Hall, Sue ;

Reed, John R. ;

Curnow, S. John ;

Fuentes-Duculan, Judilyn ;

Buckley, Christopher D. ;

Salmon, Mike ;

Taams, Leonie S. ;

Krueger, James ;

Greenwood, John ;

Klein, Nigel ;

Rustin, Malcolm H. A. ;

Akbar, Arne N. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (09) :1929-1940

[2]

Altered innate immune functioning of dendritic cells in elderly humans: A role of phosphoinositide 3-kinase-signaling pathway [J].

Agrawal, Anshu ;

Agrawal, Sudhanshu ;

Cao, Jia-Ning ;

Su, Houfen ;

Osann, Kathryn ;

Gupta, Sudhir .

JOURNAL OF IMMUNOLOGY, 2007, 178 (11) :6912-6922

[3]

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions [J].

Ahmadzadeh, Mojgan ;

Felipe-Silva, Aloisio ;

Heemskerk, Bianca ;

Powell, Daniel J., Jr. ;

Wunderlich, John R. ;

Merino, Maria J. ;

Rosenberg, Steven A. .

BLOOD, 2008, 112 (13) :4953-4960

[4]

Telomerase in T lymphocytes: Use it and lose it? [J].

Akbar, Arne N. ;

Vukmanovic-Stejic, Milica .

JOURNAL OF IMMUNOLOGY, 2007, 178 (11) :6689-6694

[5]

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? [J].

Akbar, Arne N. ;

Henson, Sian M. .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (04) :289-295

[6]

Exogenous interleukin-1β restores impaired Langerhans cell migration in aged skin [J].

Bhushan, M ;

Cumberbatch, M ;

Dearman, RJ ;

Kimber, I ;

Griffiths, CEM .

BRITISH JOURNAL OF DERMATOLOGY, 2004, 150 (06) :1217-1218

[7]

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection [J].

Blackburn, Shawn D. ;

Shin, Haina ;

Haining, W. Nicholas ;

Zou, Tao ;

Workman, Creg J. ;

Polley, Antonio ;

Betts, Michael R. ;

Freeman, Gordon J. ;

Vignali, Dario A. A. ;

Wherry, E. John .

NATURE IMMUNOLOGY, 2009, 10 (01) :29-37

[8]

Acute Ablation of Langerhans Cells Enhances Skin Immune Responses [J].

Bobr, Aleh ;

Olvera-Gomez, Irlanda ;

Igyarto, Botond Z. ;

Haley, Krystal M. ;

Hogquist, Kristin A. ;

Kaplan, Daniel H. .

JOURNAL OF IMMUNOLOGY, 2010, 185 (08) :4724-4728

[9]

The pathogenic role of tissue-resident immune cells in psoriasis [J].

Boyman, Onur ;

Conrad, Curdin ;

Tonel, Giulia ;

Gilliet, Michel ;

Nestle, Frank O. .

TRENDS IN IMMUNOLOGY, 2007, 28 (02) :51-57

[10]

ANALYSIS OF CUTANEOUS DELAYED-TYPE HYPERSENSITIVITY REACTION AND T-CELL PROLIFERATIVE RESPONSE IN ELDERLY NURSING-HOME PATIENTS - AN APPROACH TO IDENTIFYING IMMUNODEFICIENT PATIENTS [J].

CASTLE, SC ;

NORMAN, DC ;

PERLS, TT ;

CHANG, MP ;

YOSHIKAWA, TT ;

MAKINODAN, T .

GERONTOLOGY, 1990, 36 (04) :217-229

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