Local drug delivery using coated stents: New developments and future perspectives

被引：27

作者：

Tanabe, K ^{[1
]}

Regar, E ^{[1
]}

Lee, CH ^{[1
]}

Hoye, A ^{[1
]}

van der Giessen, WJ ^{[1
]}

Serruys, PW ^{[1
]}

机构：

[1] Erasmus MC, Thoraxctr, NL-3015 GD Rotterdam, Netherlands

来源：

CURRENT PHARMACEUTICAL DESIGN | 2004年 / 10卷 / 04期

关键词：

drugs; stent; restenosis;

D O I：

10.2174/1381612043453289

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Percutaneous coronary intervention has been hampered by restenosis since its inception. Many research projects including the use of various devices and systemic drug administration have shown disappointing results. The clinical data reported from trials with sirolimus- and paclitaxel- eluting stents have been very promising, such that stents with the capability of drug elution are currently attracting the medical community for the prevention of restenosis. Based on the mechanism of action of the drugs released from the stent and the target of the restenotic process, there may be 4 therapeutic objectives: anti-inflammatory, anti-proliferative, anti-migratory, and pro-endothelial healing. There are many candidate agents for drug-eluting stents, however, it now becomes clear that not all drug-eluting stents are equally effective. This article describe candidate agents which have been tested or currently under investigation, and summarize the latest information.

引用

页码：357 / 367

页数：11

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