Anaerobic production of alginate by Pseudomonas aeruginosa: Alginate restricts diffusion of oxygen

被引：98

作者：

Hassett, DJ

机构：

[1] Dept. Molec. Genet., Biochem. M., University of Cincinnati, College of Medicine, Cincinnati

[2] Dept. Molec. Genet., Biochem. M., University of Cincinnati, College of Medicine, Cincinnati, OH 45257-0524

来源：

JOURNAL OF BACTERIOLOGY | 1996年 / 178卷 / 24期

关键词：

D O I：

10.1128/jb.178.24.7322-7325.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pseudomonas aeruginosa produced alginate and elevated algD (encoding GDPmannose 6-dehydrogenase) transcription under strict anaerobic conditions, especially when using nitrate as a terminal electron acceptor. Purified alginate added to bacterial suspensions caused a decrease in growth, suggesting that alginate contributes to oxygen limitation fur the organism and likely for patients afflicted with the inherited autosomal disease cystic fibrosis.

引用

页码：7322 / 7325

页数：4

共 26 条

[1] THE RELATIONSHIP BETWEEN INFECTION AND INFLAMMATION IN THE EARLY STAGES OF LUNG-DISEASE FROM CYSTIC-FIBROSIS
BALOUGH, K
MCCUBBIN, M
WEINBERGER, M
SMITS, W
AHRENS, R
FICK, R
[J]. PEDIATRIC PULMONOLOGY, 1995, 20 (02) : 63 - 70
[2] OXYGEN-DEPENDENT UP-REGULATION OF MUCOID EXOPOLYSACCHARIDE (ALGINATE) PRODUCTION IN PSEUDOMONAS-AERUGINOSA
BAYER, AS
EFTEKHAR, F
TU, J
NAST, CC
SPEERT, DP
[J]. INFECTION AND IMMUNITY, 1990, 58 (05) : 1344 - 1349
[3] HIGH OSMOLARITY IS A SIGNAL FOR ENHANCED ALGD TRANSCRIPTION IN MUCOID AND NONMUCOID PSEUDOMONAS-AERUGINOSA STRAINS
BERRY, A
DEVAULT, JD
CHAKRABARTY, AM
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (05) : 2312 - 2317
[4] Boat T, 1989, CYSTIC FIBROSIS META, P2649
[5] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[6] OXYGEN-THERAPY, EXERCISE, AND CYSTIC-FIBROSIS
COATES, AL
[J]. CHEST, 1992, 101 (01) : 2 - 4
[7] PULMONARY DEHYDRATION AND INFECTION IN CYSTIC-FIBROSIS - EVIDENCE THAT ETHANOL ACTIVATES ALGINATE GENE-EXPRESSION AND INDUCTION OF MUCOIDY IN PSEUDOMONAS-AERUGINOSA
DEVAULT, JD
KIMBARA, K
CHAKRABARTY, AM
[J]. MOLECULAR MICROBIOLOGY, 1990, 4 (05) : 737 - 745
[8] MUCOID-TO-NONMUCOID CONVERSION IN ALGINATE-PRODUCING PSEUDOMONAS-AERUGINOSA OFTEN RESULTS FROM SPONTANEOUS MUTATIONS IN ALGT, ENCODING A PUTATIVE ALTERNATE SIGMA-FACTOR, AND SHOWS EVIDENCE FOR AUTOREGULATION
DEVRIES, CA
OHMAN, DE
[J]. JOURNAL OF BACTERIOLOGY, 1994, 176 (21) : 6677 - 6687
[9] CLONING AND EXPRESSION IN PSEUDOMONAS-AERUGINOSA OF A GENE INVOLVED IN THE PRODUCTION OF ALGINATE
GOLDBERG, JB
OHMAN, DE
[J]. JOURNAL OF BACTERIOLOGY, 1984, 158 (03) : 1115 - 1121
[10] HAAS D, 1992, PSEUDOMONAS : MOLECULAR BIOLOGY AND BIOTECHNOLOGY, P177

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