Colonic crypt organization and tumorigenesis

被引：263

作者：

Humphries, Adam ^{[1
]}

Wright, Nicholas A. ^{[1
]}

机构：

[1] Canc Res UK, London Res Inst, Histopathol Lab, London WC2A 3PX, England

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 06期

关键词：

D O I：

10.1038/nrc2392

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An appreciation of colonic crypt organization has become essential to any understanding of tumorigenesis in the colon. Intestinal crypts house tissue-specific, multipotential stem cells, which are located in the niche at the base of the intestinal crypt and are capable of regenerating all intestinal cell types. Recent advances in our understanding of crypt biology, including how mutations in stem cells become fixed and expand within the epithelium, has led to new theories on the origins of colonic adenomas and cancers.

引用

页码：415 / 424

页数：10

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