Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii

被引：247

作者：

Héritier, C

Poirel, L

Fournier, PE

Claverie, JM

Raoult, D

Nordmann, P

机构：

[1] Hop Bicetre, Serv Bacteriol Virol, Assistance Publ Hop Paris, Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France

[2] CNRS, IGS, UPR 2589, Marseille, France

[3] Univ Mediterranee, Unite Rickettsies, IFR 48, CNRS,UMR 6020,Fac Med, Marseille, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 10期

关键词：

D O I：

10.1128/AAC.49.10.4174-4179.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A chromosomally encoded oxacillinase, OXA-69, was characterized from Acinetobacter baumannii AYE. P-Lactamase OXA-69 shared 97% amino acid identity with the recently described OXA-51 enzyme of A. baumannii and 62 and 56% amino acid identity with the carbapenem-hydrolyzing oxacillinases OXA-24 and OXA-23, respectively. Biochemical characterization of the purified OXA-69 revealed a narrow-spectrum hydrolysis profile but including, at a low level, imipenem and meropenem. By PCR and sequencing bla(OXA-69)-like genes were identified in all A. baumannii strains tested (n = 12), suggesting that this oxacillinase is naturally occurring in that species.

引用

页码：4174 / 4179

页数：6

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