Altered vesicular dopamine storage in Parkinson's disease: a premature demise

被引：104

作者：

Caudle, W. Michael ^{[1
,2
]}

Colebrooke, Rebecca E. ^{[3
]}

Ernson, Piers C. ^{[3
]}

Miller, Gary W. ^{[1
,2
]}

机构：

[1] Emory Univ, Rollins Sch Publ Hlth, Ctr Neurodegenerat Dis, Atlanta, GA 30322 USA

[2] Emory Univ, Rollins Sch Publ Hlth, Dept Environm & Occupat Hlth, Atlanta, GA 30322 USA

[3] Babraharn Inst, Neurobiol Programme, Cambridge CB2 4AT, England

来源：

TRENDS IN NEUROSCIENCES | 2008年 / 31卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tins.2008.02.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Dopamine is a potentially toxic neurotransmitter that has long been speculated to contribute to the pathogenesis of Parkinson's disease (PD). Recent work has demonstrated the importance of proper storage of dopamine in vesicles to maintain dopamine homeostasis, thus protecting neurons from the detrimental effects of dopamine accumulation and breakdown in the cytosol. These studies suggest that factors which affect dopamine storage might increase the susceptibility of dopamine neurons to further environmental or genetic insults, exacerbating the neuronal degeneration that characterizes PD. This review seeks to revisit the pathogenicity of cytosolic dopamine and further address the critical role of neurotransmitter storage in dopamine-mediated neurotoxicity.

引用

页码：303 / 308

页数：6

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