Complement: central to innate immunity and bridging to adaptive responses

被引：164

作者：

Morgan, BP ^{[1
]}

Marchbank, KJ ^{[1
]}

Longhi, MP ^{[1
]}

Harris, CL ^{[1
]}

Gallimore, AM ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, Dept Med Biochem & Immunol, Cardiff CF14 4XN, S Glam, Wales

来源：

IMMUNOLOGY LETTERS | 2005年 / 97卷 / 02期

关键词：

complement; T lymphocyte; B lymphocyte;

D O I：

10.1016/j.imlet.2004.11.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complement system, a pillar of innate immunity, has belatedly become recognised as a key modulator of adaptive immunity, acting to direct, modulate and modify the responses of lymphocytes to stimuli. These effects are mediated by interactions between complement components or activation-derived fragments and specific binding proteins-complement receptors and regulators-on the target cells. This review will describe the current state of knowledge in this swiftly moving field. It is hoped that the recognition of these properties will help to establish complement in the role it richly deserves as the lynchpin of immunity. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：171 / 179

页数：9

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