Dup(10q) lacking alpha-satellite DNA in bone marrow cells of a patient with acute myeloid leukemia

被引：26

作者：

Abeliovich, D

Yehuda, O

BenNeriah, S

Kapelushnik, Y

BenYehuda, D

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,HADASSAH UNIV HOSP,DEPT HUMAN GENET,IL-91010 JERUSALEM,ISRAEL

[2] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,HADASSAH UNIV HOSP,DEPT BONE MARROW TRANSPLANTAT,IL-91010 JERUSALEM,ISRAEL

[3] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,HADASSAH UNIV HOSP,DEPT HEMATOL,IL-91010 JERUSALEM,ISRAEL

来源：

CANCER GENETICS AND CYTOGENETICS | 1996年 / 89卷 / 01期

关键词：

D O I：

10.1016/0165-4608(95)00300-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A marker chromosome was identified in leukemic cells on an AML patient. The G-banding pattern resembled an i(10q), but its centromeric position was not clear; in some cells it had a telocentric shape, in others a metacentric or acentric shape. The origin of the marker chromosome was confirmed by FISH, using chromosome-10-specific painting. To determine the centromeric position, C-banding and cu-satellite probes were applied in FISH, and none of them gave a positive signal. Despite the absence of the centromeric a-satellite sequences and the constricted feature of the centromere, the essential centromeric activity was retained in this chromosome, namely, the separation of sister chromatids in anaphase.

引用

页码：1 / 6

页数：6

共 19 条

[1] SIGNIFICANCE OF ABNORMALITIES INVOLVING CHROMOSOMAL SEGMENT 11Q22-25 IN ACUTE-LEUKEMIA
ABE, R
SANDBERG, AA
[J]. CANCER GENETICS AND CYTOGENETICS, 1984, 13 (02) : 121 - 127
[2] BLENNOW E, 1994, AM J HUM GENET, V54, P877
[3] A SURVEY OF THE GENOMIC DISTRIBUTION OF ALPHA-SATELLITE DNA ON ALL THE HUMAN-CHROMOSOMES, AND DERIVATION OF A NEW CONSENSUS SEQUENCE
CHOO, KH
VISSEL, B
NAGY, A
EARLE, E
KALITSIS, P
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (06) : 1179 - 1182
[4] A NONISOTOPIC INSITU HYBRIDIZATION STUDY OF THE CHROMOSOMAL ORIGIN OF 15 SUPERNUMERARY MARKER CHROMOSOMES IN MAN
CROLLA, JA
DENNIS, NR
JACOBS, PA
[J]. JOURNAL OF MEDICAL GENETICS, 1992, 29 (10) : 699 - 703
[5] HAYASHI Y, 1988, CANCER, V61, P712, DOI 10.1002/1097-0142(19880215)61:4<712::AID-CNCR2820610414>3.0.CO
[6] 2-6
[7] THE ORGANIZATION OF REPETITIVE SEQUENCES IN THE PERICENTROMERIC REGION OF HUMAN CHROMOSOME-10
JACKSON, MS
SLIJEPCEVIC, P
PONDER, BAJ
[J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (25) : 5865 - 5874
[8] RAPID PROCESSING OF PRIMARY EMBRYONIC TISSUES FOR CHROMOSOME BANDING PATTERN ANALYSIS
KLINGER, HP
[J]. CYTOGENETICS, 1972, 11 (05): : 424 - 435
[9] DE-NOVO FORMATION OF SEVERAL FEATURES OF A CENTROMERE FOLLOWING INTRODUCTION OF A Y-ALPHOID YAC INTO MAMMALIAN-CELLS
LARIN, Z
FRICKER, MD
TYLERSMITH, C
[J]. HUMAN MOLECULAR GENETICS, 1994, 3 (05) : 689 - 695
[10] MAGNANI I, 1993, CLIN GENET, V43, P180

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